Lipids, or fats, are essential to life. They form the membranes around cells, protecting them from the outside. In nature, there is an enormous diversity of lipids, with each organism having its own ...

The most common side effects of mRNA vaccines like the COVID-19 shot are well known: soreness, mild fever, and general ...

An AI model that screens ionizable lipids by 3D conformation identified a candidate 14.8 times more efficient than current ...

Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big impact on how well our cells absorb them, paving the way to more efficient ...

Engineers at the University of Pennsylvania have built a lipid nanoparticle that chemically fuses an IDO-pathway inhibitor ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

All the information about a person’s health (e.g., their exposure to chemicals, their inherited risks, their current illnesses) lies within their molecules, according to scientists. Thus, a team of ...