Trilemmas are everywhere. Defined as either a forced single choice among three unfavorable options or a two-out-of-three-only choice among favorable options, trilemmas involve trade-offs. The latter, ...
A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) ...
Engineering retroviruses into vectors of therapeutic value has been a highly pursued effort. To date, the promise of retroviral-mediated gene delivery to treat or even cure genetic diseases has been ...
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