For large-scale industrial production of high-value therapeutic proteins, mammalian cell lines form a vital platform. Unfortunately, this production is often hampered by low predictability and ...

A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a new study. A ...

A high throughput screen of >30,000 diverse repressor domains from across the tree of life identifies repressor domains with unique structures that underpin enhanced epigenetic effector domain potency ...

A novel study uncovers how a subtle chemical tweak transforms the naturally occurring phytotoxin into a powerful molecular glue, 12-deoxyfusicoccin (12-dFC), that locks 14-3-3 proteins onto the ...

In the quest for tomorrow’s diagnostics, therapeutics, and bioproduced drugs and fine chemicals, synthetic biologists are assembling artificial networks of genes and modular regulatory elements, ...