Mast cells are pivotal effectors in immune responses, acting as both sentinels and mediators in allergic and inflammatory processes. Their ability to rapidly degranulate and release a myriad of ...

This scanning electron microscopy image captures the moment where degranulating mast cells (pseudo-colored in sepia) attract and start to incorporate living neutrophils (pseudo-colored in cyan), ...

Known for their role in allergic reactions, mast cells have long been recognised as key players in our immune system. When they encounter allergens, they release chemicals that trigger typical allergy ...

A new study using mouse models and multi-omics analysis has traced a specific nerve pathway through which prenatal stress programs fetal skin cells for eczema-like inflammation after birth. The ...

Eosinophils and mast cells are two types of immune cells with critical roles in responding to foreign assaults. When these cells do not function properly, several disease outcomes can develop (e.g.

Barzolvolimab achieved sustained complete responses and improved quality of life in patients with CSU up to 76 weeks post-treatment. The therapy targets mast cells by inhibiting receptor tyrosine ...

New research at WashU Medicine has found that histamine-releasing immune cells cause the gates to the brain to close when bacteria are detected, blocking fluid movement out of the brain and pathogen ...

Cutaneous mastocytosis is one of two types of mastocytosis, a rare disorder in which too many mast cells — a type of white blood cell that helps the immune system function properly — accumulate in the ...

Mast-cell derived nerve growth factor drives ILC2 pro-tumoral functions in bladder cancer. New Study Reveals How Bladder Cancer “Hijacks” the Immune System — Opening Door to ...